Progressive supranuclear palsy: diagnosis, pathology, and therapy.
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منابع مشابه
Progressive supranuclear palsy: what do we know about it?
Progressive supranuclear palsy (PSP) is a progressive tauopathy characterized by supranuclear ophthalmoplegia, pseudobulbar palsy, dysarthria, axial rigidity, frontal lobe dysfunction, and dementia. The typical pathology includes neuronal loss, gliosis and microtubule-associated protein tau (MAPT)-positive inclusions in neurons and glial cells, primarily in basal ganglia, brainstem and cerebell...
متن کاملProgressive supranuclear palsy: clinical features, pathophysiology and management.
Progressive supranuclear palsy (PSP) is a degenerative condition of unknown aetiology that produces an akinetic-rigid form of parkinsonism characterised by early falls and abnormalities of extraocular movements. Mean age of onset is approximately 63 years, and mean survival from symptom onset is 9 years. Men are much more frequently affected than women. The classic clinical finding is supranucl...
متن کاملSHORT REPORT Pathological substrate for regional distribution of increased atrophy rates in progressive supranuclear palsy
Background: Most magnetic resonance imaging (MRI) studies of progressive supranuclear palsy (PSP) are crosssectional and lack post mortem confirmation of the diagnosis. MRI features described previously in PSP correspond to regions of pathological involvement demonstrated in separate studies, but serial MRI with pathological follow up has not been undertaken. Objective: To investigate whether r...
متن کاملPathological substrate for regional distribution of increased atrophy rates in progressive supranuclear palsy.
BACKGROUND Most magnetic resonance imaging (MRI) studies of progressive supranuclear palsy (PSP) are cross-sectional and lack post mortem confirmation of the diagnosis. MRI features described previously in PSP correspond to regions of pathological involvement demonstrated in separate studies, but serial MRI with pathological follow up has not been undertaken. OBJECTIVE To investigate whether ...
متن کاملConcomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer
We report the case of a 75-year-old ex-professional boxer who developed diplopia and eye movement abnormalities in his 60's followed by memory impairment, low mood and recurrent falls. Examination shortly before death revealed hypomimia, dysarthria, vertical supranuclear gaze palsy and impaired postural reflexes. Pathological examination demonstrated 4-repeat tau neuronal and glial lesions, inc...
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عنوان ژورنال:
- Journal of neural transmission. Supplementum
دوره 42 شماره
صفحات -
تاریخ انتشار 1994